解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::It is reported that chitinase1 increases in Alzheimer's disease (AD). However, the alteration of chitinase1 in the progress of AD is still unclear. Thus, we designed the present study to detect chitinase1 level in different stages of APP/PS1 double transgenic mice. Experimental models were APP/PS1 double transgenic mi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1874-4
更新日期:2016-07-01 00:00:00
abstract::This study was designed to investigate the protective effects of extracellular superoxide dismutase (SOD3) against hydrogen peroxide (H2O2) induced damage in human neuroblastoma SH-SY5Y cells and to elucidate the mechanisms responsible for this beneficial effect. SOD3-overexpressing SH-SY5Y cells were generated by ade...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1897-x
更新日期:2016-07-01 00:00:00
abstract::Level of adenosine, an endogenous astrocyte-based neuromodulator, is primarily regulated by adenosine P1 receptors. This study assessed expression of adenosine P1 receptors, ADORA1 (adenosine A1 receptor) and ADORA2A (adenosine A2a receptor) and their association with glioma development and epilepsy in glioma patients...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1893-1
更新日期:2016-07-01 00:00:00
abstract::Evidence has suggested that cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) is correlated with the development and recurrence of pain. A recent research showed that the CSF-contacting nucleus acts as a component of the descending 5-hydroxytryptamine (5-HT) system and plays a role in descending pain inh...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1880-6
更新日期:2016-07-01 00:00:00
abstract::Glioblastoma is the most common and malignant brain cancer. In spite of surgical removal, radiation and chemotherapy, this cancer recurs within short time and median survival after diagnosis is less than a year. Glioblastoma stem cells (GSCs) left in the brain after surgery is thought to explain the inevitable recurre...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1868-2
更新日期:2016-07-01 00:00:00
abstract::Recent evidence reveals that prolactin gene expression (PRL-GE) in mammotropes occurs in pulses, but the molecular process(es) underlying this phenomenon remains unclear. Earlier, we have identified an E-box (E-box133) in the rat PRL promoter that binds several circadian elements and is critical for this dynamic proce...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1843-y
更新日期:2016-06-01 00:00:00
abstract::As is known to all, neuroinflammation plays a vital role in early brain injury pathogenesis following subarachnoid hemorrhage (SAH). It has been shown that rutin have a property of inhibiting inflammation in many kinds of animal models. However, the effect of rutin on neuroinflammation after SAH remains uninvestigated...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1863-7
更新日期:2016-06-01 00:00:00
abstract::The current study demonstrates that in hippocampal neurons mitochondrial Ca(2+) processing supports Ca(2+) influx via ionotropic glutamate (Glu) receptors. We define mitochondrial Ca(2+) processing as Ca(2+) uptake via mitochondrial Ca(2+) uniporter (MCU) combined with subsequent Ca(2+) release via mitochondrial Na(+)...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1819-3
更新日期:2016-06-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common type of neurodegenerative dementia that affects the elderly population. Nerve growth factor (NGF) contributes to the survival, regeneration and death of neurons during aging and in neurodegenerative diseases. Recently, research has shown that NGF is related to the pathology,...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-016-1829-9
更新日期:2016-06-01 00:00:00
abstract::Ellagic acid (EA, 2,3,7,8-tetrahydroxy-chromeno; C14H6O8) is a polyphenol derived from fruits (pomegranates, berries) and nuts. EA exhibits antioxidant capacity and induces anti-inflammatory actions in several mammalian tissues. EA has been characterized as a possible neuroprotective agent, but the number of reports i...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-016-1853-9
更新日期:2016-06-01 00:00:00
abstract::Seizures are accompanied by an exacerbated activation of cerebral ion channels. 4-aminopyridine (4-AP) is a pro-convulsive agent which mechanism of action involves activation of Na(+) and Ca(2+) channels, and several antiepileptic drugs control seizures by reducing these channels permeability. The antidepressant, sert...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-016-1840-1
更新日期:2016-06-01 00:00:00
abstract::Neuroprotective effects of metformin have been increasingly recognized in both diabetic and non-diabetic conditions. Thus far, no information has been available on the potential beneficial effects of metformin on peripheral nerve regeneration in diabetes mellitus. The present study was designed to investigate such a p...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1803-y
更新日期:2016-05-01 00:00:00
abstract::Using the mouse maximal electroshock test, the reference model of tonic-clonic seizures, the aim of the present study was to determine the type of interaction between mexiletine (a class IB antiarrhythmic drug) and classical antiepileptics: valproate, carbamazepine, phenytoin, and phenobarbital. Isobolographic analysi...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1812-x
更新日期:2016-05-01 00:00:00
abstract::Chronic acrylamide (ACR) exposure induces peripheral-central axonopathy in occupational workers and laboratory animals, but the underlying mechanisms remain unclear. In this study, we first investigated the effects of ACR on slow axonal transport of neurofilaments in cultured rat dorsal root ganglia (DRG) neurons thro...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1782-z
更新日期:2016-05-01 00:00:00
abstract::Memory impairment is the most common symptom in patients with Alzheimer's disease. The purpose of this study is to evaluate the memory enhancing effects of P7C3, a recently identified compound with robust proneurogenic and neuroprotective effects, on the cognitive impairment induced by scopolamine, a muscarinic acetyl...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1783-y
更新日期:2016-05-01 00:00:00
abstract::Sonic hedgehog (Shh), a secreted glycoprotein factor, can activate the Shh pathway, which has been implicated in neuronal polarization involving neurite outgrowth. However, little evidence is available about the effect of Shh on neurite outgrowth in primary cortical neurons and its potential mechanism. Here, we reveal...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1736-5
更新日期:2016-04-01 00:00:00
abstract::Ion channels are targets of various antiepileptic drugs. In cerebral presynaptic nerve endings Na(+) and Ca(2+) channels are particularly abundant, as they control neurotransmitter release, including the release of glutamate (Glu), the most concentrated excitatory amino acid neurotransmitter in the brain. Several pre-...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1749-0
更新日期:2016-04-01 00:00:00
abstract::Germline mutations in genes encoding succinate dehydrogenase subunits are associated with the development of familial pheochromocytomas and paragangliomas [hereditary paraganglioma/pheochromocytoma syndrome (HPPS)]. In particular, a mutation in succinate dehydrogenase subunit B (SDHB) is highly associated with abdomin...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1738-3
更新日期:2016-04-01 00:00:00
abstract::Previous studies have demonstrated that the c-Jun N-terminal kinase (JNK) pathway plays an important role in inducing neuronal apoptosis following cerebral ischemic injury. JNK signaling pathway in activated during cerebral ischemic injury. It participates in ischemia-induced neuronal apoptosis. However, whether JNK s...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1753-4
更新日期:2016-04-01 00:00:00
abstract::Rat posterior eyecups containing the retina were prepared, loaded with [(3)H]glycine and superfused in order to determine its release originated from glycinergic amacrine cells and/or glial cells. Deprivation of oxygen and glucose from the Krebs-bicarbonate buffer used for superfusion evoked a marked increase of [(3)H...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1713-z
更新日期:2016-02-01 00:00:00
abstract::Hemin is a breakdown product of the blood protein, hemoglobin and is responsible for much of the secondary damage caused following a hemorrhagic stroke. Hemin is toxic to cultured astrocytes and it is thought that this toxicity is due to iron that is liberated when hemin is degraded. However, free iron applied to astr...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1795-7
更新日期:2016-02-01 00:00:00
abstract::Nitric oxide (NO) regulates numerous physiological process and is the main source of reactive nitrogen species (RNS). NO promotes cell survival, but it also induces apoptotic death having been involved in the pathogenesis of several neurodegenerative diseases. NO and superoxide anion react to form peroxynitrite, which...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1805-9
更新日期:2016-02-01 00:00:00
abstract::Astrocytes occupy a strategic position in the brain where they can act as an interface between neurones and blood vessels, and neurones and the cerebro-spinal fluid. This location is ideal for functioning as interoceptors, as they may sense changes in brain microenvironment and contribute to the adaptive homeostatic r...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-015-1562-9
更新日期:2015-12-01 00:00:00
abstract::During neural activity, neurotransmitters released at synapses reach neighbouring cells, such as astrocytes. These get excited via numerous mechanisms, including the G protein coupled receptors that regulate the cytosolic concentration of second messengers, such as Ca(2+) and cAMP. The stimulation of these pathways le...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-015-1545-x
更新日期:2015-12-01 00:00:00
abstract::Brain development is a highly orchestrated complex process. The developing brain utilizes many substrates including glucose, ketone bodies, lactate, fatty acids and amino acids for energy, cell division and the biosynthesis of nucleotides, proteins and lipids. Metabolism is crucial to provide energy for all cellular p...
journal_title:Neurochemical research
pub_type: 杂志文章,评审
doi:10.1007/s11064-015-1600-7
更新日期:2015-12-01 00:00:00
abstract::The Src family kinases are a family of intracellular, non-receptor tyrosine kinases that are involved in a variety of cellular functions including the regulation of inflammation and apoptosis after brain hypoxia. Caspase-1 (C1) activates IL-1β through the formation of complex structures, the inflammasomes, while caspa...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1717-8
更新日期:2015-11-01 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) is a promyelinating trophic factor that plays an important role in multiple sclerosis (MS). However, mechanisms by which CNTF expression could be increased in the brain are poorly understood. Recently we have discovered anti-inflammatory and immunomodulatory activities of sodium benz...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1723-x
更新日期:2015-11-01 00:00:00
abstract::Planarians are rapidly developing into very useful research subjects in pharmacology and neuroscience research. Here we report that curare, a cholinergic nicotinic receptor antagonist, alleviates the nicotine-induced planarian seizure-like movements (pSLM) by up to 50 % at equimolar concentrations of nicotine and cura...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1512-6
更新日期:2015-10-01 00:00:00
abstract::Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. OPs represent a human health threat, because chronic exposure to low doses can damage the developing brain, and acute exposure can produce long-lasting damage to adult brains, despite post-exposure ...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1548-7
更新日期:2015-10-01 00:00:00
abstract::Diisopropylfluorophosphate (DFP) is an irreversible inhibitor of acetylcholine esterase and a surrogate of the organophosphorus (OP) nerve agent sarin. The neurotoxicity of DFP was assessed as a reduction of population spike (PS) area elicited by synaptic stimulation in acute hippocampal slices. Two classical antidote...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1729-4
更新日期:2015-10-01 00:00:00
abstract::Ferulago angulata (Apiaceae) is a shrub indigenous to western Iran, Turkey and Iraq. In traditional medicine, F. angulata is recommended for treating digestive pains, hemorrhoids, snake bite, ulcers and as sedative. In the present study, the effects of inhaled F. angulata essential oil (1 and 3%, daily, for 21 days) o...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1662-6
更新日期:2015-09-01 00:00:00
abstract::Recent studies have demonstrated a scrutinized association of diabetes mellitus with depressive symptoms and major depression. Glycogen synthase kinase-3 (GSK-3) is a protein kinase enzyme constitutively active in non-stimulated cells and in multiple signalings. Independent lines of research provide a converging evide...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1670-6
更新日期:2015-09-01 00:00:00
abstract::Traumatic brain injury (TBI) initiates a series of neurochemical and signaling changes that could eventually lead to neuronal apoptosis. Recent studies indicated that mature neurons cell cycle re-enter played a crucial role in neuronal apoptosis. In this study, we identified that the chaperonin containing TCP-1, subun...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1683-1
更新日期:2015-09-01 00:00:00
abstract::Emerging data suggests that mitochondrial dysfunction is prominently involved in Alzheimer disease (AD) progression. Sirtuin-3 (Sirt3) is a member of the sirtuin family of nicotinamide adenine dinucleotide dependent deacetylases that regulates a variety of mitochondrial functions and suppresses mitochondria-related ph...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1630-1
更新日期:2015-08-01 00:00:00
abstract::Precise control of the proliferation and differentiation of multipotent neural stem cells (NSCs) is crucial for the proper development of the nervous system. Although cyclinD1 has been implicated as a cause of cancer in many studies, its roles in NSCs remain elusive. In this study, we examined the over-expression of c...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1635-9
更新日期:2015-08-01 00:00:00
abstract::Protocatechuic acid (PA), a major metabolite of anthocyanins, has been reported to possess antioxidant and anti-inflammatory activities. However, the effects of PA on LPS-induced inflammatory responses in microglia have not been reported. The aim of this study was to investigate the anti-inflammatory effects and molec...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1646-6
更新日期:2015-08-01 00:00:00
abstract::Aneurysmal subarachnoid hemorrhage still has a high mortality and morbidity despite notable advances in surgical approaches to cerebral aneurysm (CA). We examined the role of aspirin in vascular inflammation and degeneration. CA was induced in male Sprague-Dawley rats by ligating left common carotid artery and bilater...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1603-4
更新日期:2015-07-01 00:00:00
abstract::Mitochondrial division inhibitor 1 (Mdivi-1) is the most effective pharmacological inhibitor of mitochondrial fission. Spinal cord injury (SCI) is a common and serious trauma, which lacks efficient treatment. This study aimed to detect the role of Mdivi-1 in neuronal injury and its underlying mechanism after acute SCI...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1604-3
更新日期:2015-07-01 00:00:00
abstract::We examined the role of hippocampal metabotropic glutamate receptor 5 (mGlu5) in spatial learning and memory. Although it has been shown that mGlu5 signalling is required for certain forms of learning and memory, its role in spatial learning is unclear since studies using pharmacological or knockout mice models provid...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1595-0
更新日期:2015-06-01 00:00:00
abstract::In the present study, we investigated the effects of pioglitazone (PGZ) in the hippocampal CA1 region of low- or high-fat diet (LFD or HFD) fed gerbils after transient forebrain ischemia. After 8 weeks of LFD or HFD feeding, PGZ (30 mg/kg) was intraperitoneally administered to the gerbils, following which ischemia was...
journal_title:Neurochemical research
pub_type: 杂志文章
doi:10.1007/s11064-015-1568-3
更新日期:2015-05-01 00:00:00